A mechanobiological computer optimization framework to design scaffolds to enhance bone regeneration.

ABSTRACT: The treatment of large bone defects is a clinical challenge. 3D printed scaffolds are a promising treatment option for such critical-size defects. However, the design of scaffolds to treat such defects is challenging due to the large number of variables impacting bone regeneration; material stiffness, architecture or equivalent scaffold stiffness-due it specific architecture-have all been demonstrated to impact cell behavior and regeneration outcome. Computer design optimization is a powerful tool to find optimal design solutions within a large parameter space for given anatomical constraints. Following this approach, scaffold structures have been optimized to avoid mechanical failure while providing beneficial mechanical stimulation for bone formation within the scaffold pores immediately

SUBMITTER: Perier-Metz C 

PROVIDER: S-EPMC9490117 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature