Frequency of Intron 22 Inversion in Severe Hemophilia A Patients.

ABSTRACT:

Objective

The aim of our study was to find the frequency of Intron 22 inversion (Inv22) in severe hemophilia A (HA) patients and to evaluate the association between Inv22 and FVIII inhibitor formation.

Method

Data analysis was carried out on IBM SPSS Statistics Version 23.00 (IBM Corp, Armonk, NY). Descriptive statistics were applied to measure the frequencies, percentages, and mean ± SD of the clinical and general history of HA patients, including age, family history, inhibitor status, intron22 inversion, and FVIII levels. Chi-square was applied to evaluate the association between Inv22 and F8 inhibitor formation.

Results

A total of 62 HA patients were enrolled in the study with mean±SD age of (14.39±13.2) years. A family history of HA was observed in 36 (58.1%) pati

SUBMITTER: Ashfaq J 

PROVIDER: S-EPMC9490293 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature