Frailty and hearing loss: From association to causation.

ABSTRACT:

Background

Observational studies suggest that frailty is associated with hearing loss (HL) but with inconsistent results. This study aims to examine such association and to assess its causality.

Materials and methods

The cross-sectional data from the National Health and Nutrition Examination Survey (NHANES). Multivariate logistic regression models were used to assess the association between HL and frailty index (FI). Genetic variants associated with the FI and HL were obtained from a large genome-wide association study (GWAS) meta-analysis and UK Biobank GWAS. The inverse variance weighting (IVW) method was used to estimate causal effects. Sensitivity analyses were performed to further validate the robustness of results.

Results

In this cross-sectional analysis, resul

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9490320 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature