Plasma metabolomics and lipidomics signatures of motoric cognitive risk syndrome in community-dwelling older adults.

ABSTRACT:

Introduction

Motoric cognitive risk syndrome (MCR) is characterized by subjective cognitive complaints (SCCs) and slow gait (SG). Metabolomics and lipidomics may potentiate disclosure of the underlying mechanisms of MCR.

Methods

This was a cross-sectional study from the West China Health and Aging Trend cohort study (WCHAT). The operational definition of MCR is the presence of SCCs and SG without dementia or mobility disability. The test and analysis were based on untargeted metabolomics and lipidomics, consensus clustering, lasso regression and 10-fold cross-validation.

Results

This study enrolled 6,031 individuals for clinical analysis and 577 plasma samples for omics analysis. The overall prevalence of MCR was 9.7%, and the prevalence of MCR-only, assessed cognitiv

SUBMITTER: Li W 

PROVIDER: S-EPMC9490321 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature