Association between the metabolic profile of serum fatty acids and diabetic nephropathy: a study conducted in northeastern China.

ABSTRACT:

Background and purpose

With the progressive increase in the prevalence of type 2 diabetes mellitus (T2DM), diabetic nephropathy (DN) - one of the most common chronic microvascular complications - has evolved into a significant cause of death worldwide among end-stage renal disease patients. Academic researchers have for decades focused on the development of DN and recently found that free fatty acids (FFAs) constituted an independent risk factor for vascular complications in T2DM patients. It is therefore critical to determine whether the metabolic profile of FFAs is related to DN.

Methods

This study comprised 611 research subjects in Dalian, a city in northeast China: 52 DN patients, 115 T2DM patients, and 444 healthy controls. We determined 15 forms of serum FFAs, includin

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9490461 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature