HBx and YAP expression could promote tumor development and progression in HBV-related hepatocellular carcinoma.

ABSTRACT:

Background

Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) accounts for 10%-20% of the total HCC numbers. Its clinical features include the occurrence in the younger generation, large tumors, and poor prognosis. The contribution of hepatitis B virus X (HBx) protein in hepatocytes during activation of various oncogenic pathways has been reported. We aimed to assess the possible association between HBx and Yes-associated protein (YAP) expression in the liver tissue and the clinical features of HBV-related HCC.

Methods

The relationship between HBx and YAP expression was examined in vivo using HCC tumor and peritumor tissues (n = 55). The clinical information including tumor size, marker, and the prognosis was assessed with protein expressions. The in vi

SUBMITTER: Oda C 

PROVIDER: S-EPMC9490549 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature