Fluid Response Evaluation in Sepsis Hypotension and Shock: A Randomized Clinical Trial.

ABSTRACT:

Background

Fluid and vasopressor management in septic shock remains controversial. In this randomized controlled trial, we evaluated the efficacy of dynamic measures (stroke volume change during passive leg raise) to guide resuscitation and improve patient outcome.

Research question

Will resuscitation that is guided by dynamic assessments of fluid responsiveness in patients with septic shock improve patient outcomes?

Study design and methods

We conducted a prospective, multicenter, randomized clinical trial at 13 hospitals in the United States and United Kingdom. Patients presented to EDs with sepsis that was associated hypotension and anticipated ICU admission. Intervention arm patients were assessed for fluid responsiveness before clinically driven fluid bolus or in

SUBMITTER: Douglas IS 

PROVIDER: S-EPMC9490557 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature