Dataset Information

Perceptions of generic medicines and medication adherence after percutaneous coronary intervention: a prospective multicentre cohort study.

ABSTRACT:

Objective

To determine patient perceptions of generic medicines 2 and 6 months after percutaneous coronary intervention (PCI), and to determine whether these perceptions moderate medication adherence.

Design

Prospective multicentre cohort study with repeated measures of perceptions of generic medicines and medication adherence.

Setting

The CONCARD^PCI study conducted at seven large referral PCI centres in Norway and Denmark between June 2017 and May 2020.

Participants

A total of 3417 adults (78% men), using both generic and brand name medicines, with a mean age of 66 years (SD 11) who underwent PCI were followed up 2 and 6 months after discharge from hospital.

Main outcome measures

Perceptions of generic medicines were the main outcome. The secondary outcome was medication adherence.

Results

Perceptions of generic medicines were significantly more negative at 2 than at 6 months (1.10, 95% CI 0.41 to 1.79, p=0.002). Female sex (-4.21, 95% CI -6.75 to -1.71, p=0.001), older age (-0.12, 95% CI -0.23 to -0.02, p=0.020), lower education level (overall p<0.001), ethnicity (overall p=0.002), Norwegian nationality (10.27, 95% CI 8.19 to 12.40, p<0.001) and reduced self-reported health status (0.19, 95% CI 0.09 to 0.41, p=0.003) were significantly associated with negative perceptions of generic medicines. There was no evidence to suggest that perceptions of generic medicines moderate the association between sociodemographic and clinical variables and medication adherence (p≥0.077 for all covariates). Moreover, self-reported medication adherence was high, with 99% scoring at or above the Medication Adherence Report Scale midpoint at both time points. There were no substantial correlations between negative perceptions of generic medicines and medication non-adherence at 2 months (r=0.041, 95% CI 0.002 to 0.081, p=0.037) or 6 months (r=0.038, 95% CI -0.005 to 0.081, p=0.057).

Conclusions

Mistrust and uncertainty about the safety and efficacy of generic medicines remains in a sizeable proportion of patients after PCI. This applies especially to those of lower socioeconomic status, older age, female sex, immigrants and those with poorer mental health. However, this study demonstrated a shift towards more positive perceptions of generic medicines in the longer term.

SUBMITTER: Pettersen TR

PROVIDER: S-EPMC9490600 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Publications

Perceptions of generic medicines and medication adherence after percutaneous coronary intervention: a prospective multicentre cohort study.

Pettersen Trond Røed TR Schjøtt Jan J Allore Heather G HG Bendz Bjørn B Borregaard Britt B Fridlund Bengt B Larsen Alf Inge AI Nordrehaug Jan Erik JE Rotevatn Svein S Wentzel-Larsen Tore T Norekvål Tone Merete TM

BMJ open 20220920 9

<h4>Objective</h4>To determine patient perceptions of generic medicines 2 and 6 months after percutaneous coronary intervention (PCI), and to determine whether these perceptions moderate medication adherence.<h4>Design</h4>Prospective multicentre cohort study with repeated measures of perceptions of generic medicines and medication adherence.<h4>Setting</h4>The CONCARD<sup>PCI</sup> study conducted at seven large referral PCI centres in Norway and Denmark between June 2017 and May 2020.<h4>Parti ...[more]

PMID: 36127123

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Dataset Information

Perceptions of generic medicines and medication adherence after percutaneous coronary intervention: a prospective multicentre cohort study.

Objective

Design

Setting

Participants

Main outcome measures

Results

Conclusions

Publications

Perceptions of generic medicines and medication adherence after percutaneous coronary intervention: a prospective multicentre cohort study.

Similar Datasets

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