Preserving and rejuvenating old organs for transplantation: novel treatments including the potential of senolytics.

ABSTRACT:

Purpose of review

Older donors have the potential to close the gap between demand and supply in solid organs transplantation. Utilizing older organs, at the same time, has been associated with worse short- and long-term outcomes. Here, we introduce potential mechanisms on how treatments during machine perfusion (MP) may safely improve the utilization of older organs.

Recent findings

Consequences of ischemia reperfusion injury (IRI), a process of acute, sterile inflammation leading to organ injury are more prominent in older organs. Of relevance, organ age and IRI seem to act synergistically, leading to an increase of damage associated molecular patterns that trigger innate and adaptive immune responses. While cold storage has traditionally been considered the standard of car

SUBMITTER: Matsunaga T 

PROVIDER: S-EPMC9490781 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature