Toward Coordination Cages with Hybrid Chirality: Amino Acid-Induced Chirality on Metal Centers.

ABSTRACT: Tripodal chiral ligands containing amino acid residues and salicyl-acylhydrazone units were synthesized and used to obtain coordination cages through deprotonation and coordination to gallium. These coordination cages have Ga₃L₂ stoichiometry and pinwheel geometry with two types of chiral centers built into their walls: stereogenic centers at the amino acid backbones and stereoselectively induced centers at metal ions. The pinwheel geometry is unique among analogous cages and originates from the partial flexibility of the ligands. Despite the flexibility, the ligands induce the chirality of metal centers in a highly stereoselective way, leading to the formation of cages that are single diastereoisomers. It has also been demonstrated that stereoselectivity is a unique

SUBMITTER: Grajda M 

PROVIDER: S-EPMC9490811 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature