Synthetic Approach toward Enantiopure Cyclic Sulfinamides.

ABSTRACT: A synthetic approach toward densely substituted enantiopure cyclic sulfinamides possessing up to four consecutive stereogenic centers was developed based on a completely diastereoselective S_N2' cyclization/tert-Bu cleavage sequence. Diastereospecific transformation of the obtained scaffold into chiral S^VI derivatives such as sulfoximines and sulfonimidamides is demonstrated.

SUBMITTER: Jersovs G 

PROVIDER: S-EPMC9490816 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature