Ancestry-related distribution of Runs of homozygosity and functional variants in Qatari population.

ABSTRACT:

Background

Describing how genetic history shapes the pattern of medically relevant variants could improve the understanding of how specific loci interact with each other and affect diseases and traits prevalence. The Qatari population is characterized by a complex history of admixture and substructure, and the study of its population genomic features would provide valuable insights into the genetic landscape of functional variants. Here, we analyzed the genomic variation of 186 newly-genotyped healthy individuals from the Qatari peninsula.

Results

We discovered an intricate genetic structure using ancestry related analyses. In particular, the presence of three different clusters, Cluster 1, Cluster 2 and Cluster 3 (with Near Eastern, South Asian and African ancestry, respect

SUBMITTER: Mezzavilla M 

PROVIDER: S-EPMC9490902 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature