Activation of oxytocin receptors in mouse GABAergic amacrine cells modulates retinal dopaminergic signaling.

ABSTRACT:

Background

Oxytocin, secreted by oxytocin neurons in the hypothalamus, is an endogenous neuropeptide involved in modulating multiple sensory information processing pathways, and its roles in the brain have been associated with prosocial, maternal, and feeding-related behaviors. Visual information is necessary for initiating these behaviors, with the retina consisting of the first stage in the visual system mediating external stimulus perception. Oxytocin has been detected in the mammalian retina; however, the expression and possible function of oxytocin receptors (OxtR) in the retina remain unknown. Here, we explore the role of oxytocin in regulating visual information processing in the retina.

Results

We observed that OxtR mRNA and protein are expressed in the mouse retina.

SUBMITTER: Hu S 

PROVIDER: S-EPMC9490981 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature