Global Sensitivity Analysis of Four Chamber Heart Hemodynamics Using Surrogate Models.

ABSTRACT: Computational Fluid Dynamics (CFD) is used to assist in designing artificial valves and planning procedures, focusing on local flow features. However, assessing the impact on overall cardiovascular function or predicting longer-term outcomes may requires more comprehensive whole heart CFD models. Fitting such models to patient data requires numerous computationally expensive simulations, and depends on specific clinical measurements to constrain model parameters, hampering clinical adoption. Surrogate models can help to accelerate the fitting process while accounting for the added uncertainty. We create a validated patient-specific four-chamber heart CFD model based on the Navier-Stokes-Brinkman (NSB) equations and test Gaussian Process Emulators (GPEs) as a surrogate model for performing

SUBMITTER: Karabelas E 

PROVIDER: S-EPMC9491017 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature