Ultrafast transverse relaxation exchange NMR spectroscopy.

ABSTRACT: Molecular exchange between different physical or chemical environments occurs due to either diffusion or chemical transformation. Nuclear magnetic resonance (NMR) spectroscopy provides a means of understanding the molecular exchange in a noninvasive way and without tracers. Here, we introduce a novel two dimensional, single-scan ultrafast Laplace NMR (UF LNMR) method to monitor molecular exchange using transverse relaxation as a contrast. The UF T₂-T₂ relaxation exchange spectroscopy (REXSY) method shortens the experiment time by one to two orders of magnitude compared to its conventional counterpart. Contrary to the conventional EXSY, the exchanging sites are distinguished based on T₂ relaxation times instead of chemical shifts, making

SUBMITTER: Ullah MS 

PROVIDER: S-EPMC9491048 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature