Genetic assortative mating for schizophrenia and bipolar disorder.

ABSTRACT:

Background

Psychiatric disorders are highly polygenic and show patterns of partner resemblance. Partner resemblance has direct population-level genetic implications if it is caused by assortative mating, but not if it is caused by convergence or social homogamy. Using genetics may help distinguish these different mechanisms. Here, we investigated whether partner resemblance for schizophrenia and bipolar disorder is influenced by assortative mating using polygenic risk scores (PRSs).

Methods

PRSs from The Danish High-Risk and Resilience Study-VIA 7 were compared between parents in three subsamples: population-based control parent pairs (N=198), parent pairs where at least one parent had schizophrenia (N=193), and parent pairs where at least one parent had bipola

SUBMITTER: Jefsen OH 

PROVIDER: S-EPMC9491077 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature