Controlled Human Infection Models To Accelerate Vaccine Development.

ABSTRACT: The timelines for developing vaccines against infectious diseases are lengthy, and often vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of protective efficacy. The application of controlled human challenge models of infection and disease at the appropriate stages of development could accelerate development of candidate vaccines and, in fact, has done so successfully in some limited cases. Human challenge models could potentially be used to gather critical information on pathogenesis, inform strain selection for vaccines, explore cross-protective immunity, identify immune correlates of protection and mechanisms of protection induced by infection or evoked by candidate vaccines, guide decisions on appropriate trial endpoints, and evaluate vaccin

SUBMITTER: Choy RKM 

PROVIDER: S-EPMC9491212 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature