Comparison of Antimicrobial and Antibiofilm Activity of Proflavine Co-crystallized with Silver, Copper, Zinc, and Gallium Salts.

ABSTRACT: Here, we exploit our mechanochemical synthesis for co-crystallization of an organic antiseptic, proflavine, with metal-based antimicrobials (silver, copper, zinc, and gallium). Our previous studies have looked for general antimicrobial activity for the co-crystals: proflavine·AgNO₃, proflavine·CuCl, ZnCl₃[Proflavinium], [Proflavinium]₂[ZnCl₄]·H₂O, and [Proflavinium]₃[Ga(oxalate)₃]·4H₂O. Here, we explore and compare more precisely the bacteriostatic (minimal inhibitory concentrations) and antibiofilm (prevention of cell attachment and propagation) activities of the co-crystals. For this, we choose three prominent "ESKAPE" bacterial pathogens of Pseudomonas aeruginosa, Escherichia coli, and

SUBMITTER: Lekhan A 

PROVIDER: S-EPMC9491326 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature