Conditional GWAS of non-CG transposon methylation in Arabidopsis thaliana reveals major polymorphisms in five genes.
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ABSTRACT:
SUBMITTER: Sasaki E
PROVIDER: S-EPMC9491579 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Publications
Conditional GWAS of non-CG transposon methylation in Arabidopsis thaliana reveals major polymorphisms in five genes.
Sasaki Eriko E Gunis Joanna J Reichardt-Gomez Ilka I Nizhynska Viktoria V Nordborg Magnus M
PLoS genetics 20220909 9
Genome-wide association studies (GWAS) have revealed that the striking natural variation for DNA CHH-methylation (mCHH; H is A, T, or C) of transposons has oligogenic architecture involving major alleles at a handful of known methylation regulators. Here we use a conditional GWAS approach to show that CHG-methylation (mCHG) has a similar genetic architecture-once mCHH is statistically controlled for. We identify five key trans-regulators that appear to modulate mCHG levels, and show that they in ...[more]
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