Donor-derived urologic cancers after renal transplantation: A retrospective non-randomized scientific analysis.

ABSTRACT:

Background

Malignancies in the urinary tract and the kidney graft are quite common after kidney transplantation. In some selected cases tumours develop from donor-derived tissue.

Objectives

We hypothesised that there is a clinical value to investigate donor/recipient origin in urologic malignancies in renal transplant recipients.

Methods

In this retrospective study, including patients transplanted between the years 1969 and 2014 at Uppsala University Hospital, Sweden, 11 patients with malignancies in urinary tract and 4 patients with malignancies in kidney transplants were investigated. Donor/recipient origin of tumour tissue was analysed by polymerase chain reaction (PCR) of human leucocyte antigen (HLA) genotypes or by fluorescence in situ hybridization (FISH analys

SUBMITTER: Hellstrom V 

PROVIDER: S-EPMC9491581 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature