A transcriptional cycling model recapitulates chromatin-dependent features of noisy inducible transcription.

ABSTRACT: Activation of gene expression in response to environmental cues results in substantial phenotypic heterogeneity between cells that can impact a wide range of outcomes including differentiation, viral activation, and drug resistance. An important source of gene expression noise is transcriptional bursting, or the process by which transcripts are produced during infrequent bursts of promoter activity. Chromatin accessibility impacts transcriptional bursting by regulating the assembly of transcription factor and polymerase complexes on promoters, suggesting that the effect of an activating signal on transcriptional noise will depend on the initial chromatin state at the promoter. To explore this possibility, we simulated transcriptional activation using a transcriptional cycling model with th

SUBMITTER: Bullock ME 

PROVIDER: S-EPMC9491597 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature