Alteration of rhesus macaque serum N-glycome during infection with the human parasitic filarial nematode Brugia malayi.

ABSTRACT: Serum N-glycan profiling studies during the past decades have shown robust associations between N-glycan changes and various biological conditions, including infections, in humans. Similar studies are scarcer for other mammals, despite the tremendous potential of serum N-glycans as biomarkers for infectious diseases in animal models of human disease and in the veterinary context. To expand the knowledge of serum N-glycan profiles in important mammalian model systems, in this study, we combined MALDI-TOF-MS analysis and HILIC-UPLC profiling of released N-glycans together with glycosidase treatments to characterize the glycan structures present in rhesus macaque serum. We used this baseline to monitor changes in serum N-glycans during infection with Brugia malayi, a parasitic nematode of hum

SUBMITTER: Petralia LMC 

PROVIDER: S-EPMC9491660 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature