Increased expression of SYCP2 predicts poor prognosis in patients suffering from breast carcinoma.

ABSTRACT: Overexpression of synaptonemal complex protein-2 (SYCP2) has been identified in various human papillomavirus (HPV)-related carcinomas, whereas its significant role in breast carcinoma remains unclear. The aim of this study was to elucidate the prognostic value and potential function of SYCP2 in breast carcinoma. Herein, data for breast carcinoma patients from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas database (TCGA) were analyzed. The enrichment analysis of SYCP2 including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Friends, and GSEA was performed. Kaplan-Meier analysis, Cox regression, and receiver operating characteristic (ROC) curves were employed for determining the predictive value of SYCP2 on clinical outcomes in

SUBMITTER: Zheng H 

PROVIDER: S-EPMC9491682 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature