Enhancing GAT-3 in thalamic astrocytes promotes resilience to brain injury in rodents.

ABSTRACT: Inflammatory processes induced by brain injury are important for recovery; however, when uncontrolled, inflammation can be deleterious, likely explaining why most anti-inflammatory treatments have failed to improve neurological outcomes after brain injury in clinical trials. In the thalamus, chronic activation of glial cells, a proxy of inflammation, has been suggested as an indicator of increased seizure risk and cognitive deficits that develop after cortical injury. Furthermore, lesions in the thalamus, more than other brain regions, have been reported in patients with viral infections associated with neurological deficits, such as SARS-CoV-2. However, the extent to which thalamic inflammation is a driver or by-product of neurological deficits remains unknown. Here, we found that thalami

SUBMITTER: Cho FS 

PROVIDER: S-EPMC9491689 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature