Label-free hyperspectral imaging and deep-learning prediction of retinal amyloid β-protein and phosphorylated tau.

ABSTRACT: Alzheimer's disease (AD) is a major risk for the aging population. The pathological hallmarks of AD-an abnormal deposition of amyloid β-protein (Aβ) and phosphorylated tau (pTau)-have been demonstrated in the retinas of AD patients, including in prodromal patients with mild cognitive impairment (MCI). Aβ pathology, especially the accumulation of the amyloidogenic 42-residue long alloform (Aβ₄₂), is considered an early and specific sign of AD, and together with tauopathy, confirms AD diagnosis. To visualize retinal Aβ and pTau, state-of-the-art methods use fluorescence. However, administering contrast agents complicates the imaging procedure. To address this problem from fundamentals, ex-vivo studies were performed to develop a label-free hyperspectral imaging method to detect th

SUBMITTER: Du X 

PROVIDER: S-EPMC9491695 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature