Higher body mass index is associated with worse hippocampal vasoreactivity to carbon dioxide.

ABSTRACT:

Background and objectives

Obesity is a risk factor for cognitive decline. Probable mechanisms involve inflammation and cerebrovascular dysfunction, leading to diminished cerebral blood flow (CBF) and cerebrovascular reactivity (CVR). The hippocampus, crucially involved in memory processing and thus relevant to many types of dementia, poses a challenge in studies of perfusion and CVR, due to its location, small size, and complex shape. We examined the relationships between body mass index (BMI) and hippocampal resting CBF and CVR to carbon dioxide (CVR_CO2) in a group of cognitively normal middle-aged and older adults.

Methods

Our study was a retrospective analysis of prospectively collected data. Subjects were enrolled for studies assessing the role of hippocampal

SUBMITTER: Glodzik L 

PROVIDER: S-EPMC9491849 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature