Chronic thromboembolic pulmonary hypertension and impairment after pulmonary embolism: the FOCUS study.

ABSTRACT:

Aims

To systematically assess late outcomes of acute pulmonary embolism (PE) and to investigate the clinical implications of post-PE impairment (PPEI) fulfilling prospectively defined criteria.

Methods and results

A prospective multicentre observational cohort study was conducted in 17 large-volume centres across Germany. Adult consecutive patients with confirmed acute symptomatic PE were followed with a standardized assessment plan and pre-defined visits at 3, 12, and 24 months. The co-primary outcomes were (i) diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH), and (ii) PPEI, a combination of persistent or worsening clinical, functional, biochemical, and imaging parameters during follow-up. A total of 1017 patients (45% women, median age 64 years) were incl

SUBMITTER: Valerio L 

PROVIDER: S-EPMC9492241 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature