Malignant clonal evolution drives multiple myeloma cellular ecological diversity and microenvironment reprogramming.

ABSTRACT:

Background

Multiple myeloma (MM) is a heterogeneous disease with different patterns of clonal evolution and a complex tumor microenvironment, representing a challenge for clinicians and pathologists to understand and dissect the contribution and impact of polyclonality on tumor progression.

Methods

In this study, we established a global cell ecological landscape of the bone marrow (BM) from MM patients, combining single-cell RNA sequencing and single-molecule long-read genome sequencing data.

Results

The malignant mutation event was localized to the tumor cell clusters with shared mutation of ANK1 and IFITM2 in all malignant subpopulations of all MM patients. Therefore, these two variants occur in the early stage of malignant clonal origin to mediate the malignant tra

SUBMITTER: Liang Y 

PROVIDER: S-EPMC9492468 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature