Omicron neutralizing antibody response following booster vaccination compared with breakthrough infection.

ABSTRACT:

Background

The spread of the vaccine-resistant Omicron severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants threatens unvaccinated and fully vaccinated individuals, and accelerated booster vaccination campaigns are underway to mitigate the ongoing wave of Omicron cases. The immunity provided by standard vaccine regimens, boosted regimens, and immune responses elicited by vaccination plus natural infection remain incompletely understood. The magnitude, quality, and durability of serological responses, and the likelihood of protection against future SARS-CoV-2 variants following these modes of exposure, are poorly characterized but are critical to the future trajectory of the coronavirus disease 2019 (COVID-19) pandemic.

Methods

Ninety-nine individuals were se

SUBMITTER: Curlin ME 

PROVIDER: S-EPMC9492511 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature