Individual differences in neuroanatomy and neurophysiology predict effects of transcranial alternating current stimulation.

ABSTRACT:

Background

Noninvasive transcranial electrical stimulation (tES) research has been plagued with inconsistent effects. Recent work has suggested neuroanatomical and neurophysiological variability may alter tES efficacy. However, direct evidence is limited.

Objective

We have previously replicated effects of transcranial alternating current stimulation (tACS) on improving multitasking ability in young adults. Here, we attempt to assess whether these stimulation parameters have comparable effects in older adults (aged 60-80 years), which is a population known to have greater variability in neuroanatomy and neurophysiology. It is hypothesized that this variability in neuroanatomy and neurophysiology will be predictive of tACS efficacy.

Methods

We conducted a pre-registered

SUBMITTER: Zanto TP 

PROVIDER: S-EPMC9492518 | biostudies-literature | 2021 Sep-Oct

REPOSITORIES: biostudies-literature