Brainstem ADCYAP1⁺ neurons control multiple aspects of sickness behaviour.

ABSTRACT: Infections induce a set of pleiotropic responses in animals, including anorexia, adipsia, lethargy and changes in temperature, collectively termed sickness behaviours¹. Although these responses have been shown to be adaptive, the underlying neural mechanisms have not been elucidated^2-4. Here we use of a set of unbiased methodologies to show that a specific subpopulation of neurons in the brainstem can control the diverse responses to a bacterial endotoxin (lipopolysaccharide (LPS)) that potently induces sickness behaviour. Whole-brain activity mapping revealed that subsets of neurons in the nucleus of the solitary tract (NTS) and the area postrema (AP) acutely express FOS after LPS treatment, and we found that subsequent reactivation of these specific neurons in FOS

SUBMITTER: Ilanges A 

PROVIDER: S-EPMC9492535 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature