Possible mediators of metabolic endotoxemia in women with obesity and women with obesity-diabetes in The Gambia.

ABSTRACT:

Aims/hypothesis

Translocation of bacterial debris from the gut causes metabolic endotoxemia (ME) that results in insulin resistance, and may be on the causal pathway to obesity-related type 2 diabetes. To guide interventions against ME we tested two hypothesised mechanisms for lipopolysaccharide (LPS) ingress: a leaky gut and chylomicron-associated transfer following a high-fat meal.

Methods

In lean women (n = 48; fat mass index (FMI) 9.6 kg/m²), women with obesity (n = 62; FMI 23.6 kg/m²) and women with obesity-diabetes (n = 38; FMI 24.9 kg/m²) we used the lactulose-mannitol dual-sugar permeability test (LM ratio) to assess gut integrity. Markers of ME (LPS, EndoCAb IgG and IgM, IL-6, CD14 and lipoprotein binding protein) were assessed at ba

SUBMITTER: Jobe M 

PROVIDER: S-EPMC9492538 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature