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Delta-like 4-Derived Notch Signals Differentially Regulate Thymic Generation of Skin-Homing CCR10⁺NK1.1⁺ Innate Lymphoid Cells at Neonatal and Adult Stages.

ABSTRACT: The thymus is a primary lymphoid organ for T cell development. Increasing evidence found that the thymus is also an important site for development of innate lymphoid cells (ILCs). ILCs generated in thymi acquire unique homing properties that direct their localization into barrier tissues such as the skin and intestine, where they help local homeostasis. Mechanisms underlying the developmental programming of unique tissue-homing properties of ILCs are poorly understood. We report in this article that thymic stroma-derived Notch signaling is differentially involved in thymic generation of a population of NK1.1⁺ group 1 ILCs (ILC1s) with the CCR10⁺ skin-homing property in adult and neonatal mice. We found that thymic generation of CCR10⁺NK1.1⁺ ILC1s

SUBMITTER: Song EH

PROVIDER: S-EPMC9492633 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Dataset Information

Delta-like 4-Derived Notch Signals Differentially Regulate Thymic Generation of Skin-Homing CCR10⁺NK1.1⁺ Innate Lymphoid Cells at Neonatal and Adult Stages.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Delta-like 4-Derived Notch Signals Differentially Regulate Thymic Generation of Skin-Homing CCR10+NK1.1+ Innate Lymphoid Cells at Neonatal and Adult Stages.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Delta-like 4-Derived Notch Signals Differentially Regulate Thymic Generation of Skin-Homing CCR10⁺NK1.1⁺ Innate Lymphoid Cells at Neonatal and Adult Stages.