PLCβ2 Promotes VEGF-Induced Vascular Permeability.

ABSTRACT:

Background

Regulation of vascular permeability is critical to maintaining tissue metabolic homeostasis. VEGF (vascular endothelial growth factor) is a key stimulus of vascular permeability in acute and chronic diseases including ischemia reperfusion injury, sepsis, and cancer. Identification of novel regulators of vascular permeability would allow for the development of effective targeted therapeutics for patients with unmet medical need.

Methods

In vitro and in vivo models of VEGFA-induced vascular permeability, pathological permeability, quantitation of intracellular calcium release and cell entry, and phosphatidylinositol 4,5-bisphosphate levels were evaluated with and without modulation of PLC (phospholipase C) β2.

Results

Global knock-out of PLCβ2 in mice

SUBMITTER: Phoenix KN 

PROVIDER: S-EPMC9492642 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature