Preclinical comparative study of [¹⁸F]AlF-PSMA-11 and [¹⁸F]PSMA-1007 in varying PSMA expressing tumors.

ABSTRACT: A wide variety of ¹⁸F-labeled PSMA-targeting PET radiotracers have been developed, including [¹⁸F]AlF-PSMA-11. As there is only limited data on the comparison with other ¹⁸F-labeled PSMA PET tracers, a comparative preclinical study between [¹⁸F]AlF-PSMA-11 and [¹⁸F]PSMA-1007 was conducted. Mice with varying PSMA expressing tumors (C4-2, 22Rv1 and PC-3, each n = 5) underwent two PET/CT scans with both [¹⁸F]AlF-PSMA-11 and [¹⁸F]PSMA-1007. Ten additional mice bearing C4-2 xenografts were subjected to ex vivo biodistribution with either [¹⁸F]AlF-PSMA-11 (n = 5) or [¹⁸F]PSMA-1007 (n = 5). Absolute SUV_mean and SUV_max values were significantly higher for [¹⁸F]PSMA-10

SUBMITTER: Piron S 

PROVIDER: S-EPMC9492661 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature