ZIKV-envelope proteins induce specific humoral and cellular immunity in distinct mice strains.

ABSTRACT: Recent outbreaks of Zika virus (ZIKV) infection have highlighted the need for a better understanding of ZIKV-specific immune responses. The ZIKV envelope glycoprotein (E_ZIKV) is the most abundant protein on the virus surface and it is the main target of the protective immune response. E_ZIKV protein contains the central domain (EDI), a dimerization domain containing the fusion peptide (EDII), and a domain that binds to the cell surface receptor (EDIII). In this study, we performed a systematic comparison of the specific immune response induced by different E_ZIKV recombinant proteins (E_ZIKV, EDI/II_ZIKV or EDIII_ZIKV) in two mice strains. Immunization induced high titers of E-specific antibodies which recognized ZIKV-infected ce

SUBMITTER: Lunardelli VAS 

PROVIDER: S-EPMC9492693 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature