Depression and bipolar disorder subtypes differ in their genetic correlations with biological rhythms.

ABSTRACT: Major Depression and Bipolar Disorder Type I (BIP-I) and Type II (BIP-II), are characterized by depressed, manic, and hypomanic episodes in which specific changes of physical activity, circadian rhythm, and sleep are observed. It is known that genetic factors contribute to variation in mood disorders and biological rhythms, but unclear to what extent there is an overlap between their underlying genetics. In the present study, data from genome-wide association studies were used to examine the genetic relationship between mood disorders and biological rhythms. We tested the genetic correlation of depression, BIP-I, and BIP-II with physical activity (overall physical activity, moderate activity, sedentary behaviour), circadian rhythm (relative amplitude), and sleep features (sleep duration, d

SUBMITTER: Sirignano L 

PROVIDER: S-EPMC9492698 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature