Efficacy of psychotropic medications on suicide and self-injury: a meta-analysis of randomized controlled trials.

ABSTRACT: Using psychotropic medications to treat and prevent self-injurious thoughts and behaviors (SITBs) has become increasingly popular, but conclusive evidence supporting the efficacy this approach remains elusive. To empirically examine whether psychotropic medications are efficacious treatments for SITBs, the present meta-analysis comprehensively summarizes all published randomized controlled trials (RCTs) that have reported the causal effects of psychotropic medications on suicide and self-injury. A total of 251 papers from 718 unique RCTs were included. A frequentist pairwise approach was adopted for meta-analyses. Potential effect modifiers were examined via met regressions and potential biases were evaluated through sensitivity analyses. On average, medications yielded an 8% reduction in

SUBMITTER: Huang X 

PROVIDER: S-EPMC9492722 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature