Vesicle trafficking and vesicle fusion: mechanisms, biological functions, and their implications for potential disease therapy.

ABSTRACT: Intracellular vesicle trafficking is the fundamental process to maintain the homeostasis of membrane-enclosed organelles in eukaryotic cells. These organelles transport cargo from the donor membrane to the target membrane through the cargo containing vesicles. Vesicle trafficking pathway includes vesicle formation from the donor membrane, vesicle transport, and vesicle fusion with the target membrane. Coat protein mediated vesicle formation is a delicate membrane budding process for cargo molecules selection and package into vesicle carriers. Vesicle transport is a dynamic and specific process for the cargo containing vesicles translocation from the donor membrane to the target membrane. This process requires a group of conserved proteins such as Rab GTPases, motor adaptors, and motor prot

SUBMITTER: Cui L 

PROVIDER: S-EPMC9492833 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature