Exosomes and exosomal miRNAs: A new therapy for intervertebral disc degeneration.

ABSTRACT: Low back pain has been found as a major cause of global disease burden and disability. Intervertebral disc degeneration is recognized as the vital factor causing low back pain. Intervertebral disc degeneration has a complex mechanism and cannot be avoided. Traditional strategies for the treatment of intervertebral disc degeneration cannot meet the needs of intervertebral disc regeneration, so novel treatment methods are urgently required. Exosomes refer to extracellular vesicles that can be released by most cells, and play major roles in intercellular material transport and information transmission. MicroRNAs have been identified as essential components in exosomes, which can be selectively ingested by exosomes and delivered to receptor cells for the regulation of the physiological activit

SUBMITTER: Li Z 

PROVIDER: S-EPMC9492865 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature