Analysis of HIF2α polymorphisms in infertile women with polycystic ovary syndrome or unexplained infertility.

ABSTRACT:

Objective

To evaluate HIF2α polymorphisms and glucose metabolism in a group of women with polycystic ovary syndrome (PCOS) or unexplained infertility (UI).

Patients

The infertile group (n=148) consisted of 96 women with PCOS, 52 women with UI, and176 women without infertility as a healthy control group.

Intervention

We genotyped 29 single nucleotide polymorphisms (SNPs) of HIF2α by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS)-based genotyping technology. The genetic associations were analyzed statistically.

Main outcome measures

Allele frequency, genotype distribution and haplotype analyze of the HIF2α polymorphisms were performed. Body mass index (BMI), waist circumference, uric acid (UA), high-sensitivity C

SUBMITTER: Zheng X 

PROVIDER: S-EPMC9492870 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature