Sex-dependent effects of multiple acute concurrent stresses on memory: a role for hippocampal estrogens.

ABSTRACT: Memory disruption commonly follows chronic stress, whereas acute stressors are generally benign. However, acute traumas such as mass shootings or natural disasters-lasting minutes to hours and consisting of simultaneous physical, social, and emotional stresses-are increasingly recognized as significant risk factors for memory problems and PTSD. Our prior work has revealed that these complex stresses (concurrent multiple acute stresses: MAS) disrupt hippocampus-dependent memory in male rodents. In females, the impacts of MAS are estrous cycle-dependent: MAS impairs memory during early proestrus (high estrogens phase), whereas the memory of female mice stressed during estrus (low estrogens phase) is protected. Female memory impairments limited to high estrogens phases suggest that higher lev

SUBMITTER: Hokenson RE 

PROVIDER: S-EPMC9492881 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature