Association of methylenetetrahydrofolate reductase gene polymorphisms and maternal folic acid use with the risk of congenital heart disease.

ABSTRACT:

Background

To systematically evaluate the association of MTHFR genetic polymorphisms, maternal folic acid intake, and the time when folic acid intake was started with the risk of congenital heart disease (CHD) and investigated the role of their interaction on infant CHD risk in Chinese populations.

Methods

A case-control study involving 592 CHD cases, 617 health controls, and their mothers was performed. The exposures of interest were single nucleotide polymorphisms (SNPs) of the MTHFR gene, maternal folic acid use, and the time when folic acid use was started. We applied the logistic regression model to explore the strength of association.

Results

Our findings showed that mothers lacking folic acid intake had a significantly higher risk of CHD in offspr

SUBMITTER: Zhong T 

PROVIDER: S-EPMC9492935 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature