Impaired dynamic cerebral autoregulation: A potential mechanism of orthostatic hypotension and dementia in Parkinson's disease.

ABSTRACT:

Background

Orthostatic hypotension (OH) and cognitive impairment are common non-motor symptoms of Parkinson's disease (PD). This study aimed to investigate whether impaired dynamic cerebral autoregulation (dCA) is associated with OH and Parkinson's disease dementia (PDD), and analyze the related risk factors in patients with PDD.

Materials and methods

We enrolled 89 patients with PD and 20 age- and sex-matched healthy controls (HCs). Cognition and different cognitive domains were assessed by the Montreal Cognitive Assessment scale. Non-invasive continuous beat-to-beat blood pressure and cerebral blood flow velocity were assessed using a servo-controlled finger plethysmograph and transcranial Doppler, respectively. dCA was examined using supine and orthostatic changes with tr

SUBMITTER: Chen H 

PROVIDER: S-EPMC9492951 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature