Reduced phonemic fluency in progressive supranuclear palsy is due to dysfunction of dominant BA6.

ABSTRACT:

Background

Reduced phonemic fluency is extremely frequent in progressive supranuclear palsy (PSP), but its neural correlate is yet to be defined.

Objective

We explored the hypothesis that poor fluency in PSP might be due to neurodegeneration within a dominant frontal circuit known to be involved in speech fluency, including the opercular area, the superior frontal cortex (BA6), and the frontal aslant tract connecting these two regions.

Methods

We correlated performance on a letter fluency task (F, A, and S, 60 s for each letter) with brain metabolism as measured with Fluoro-deoxy-glucose Positron Emission Tomography, using Statistical Parametric Mapping, in 31 patients with PSP.

Results

Reduced letter fluency was associated with significant hypometabolism at th

SUBMITTER: Isella V 

PROVIDER: S-EPMC9492952 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature