The regulatory roles of T helper cells in distinct extracellular matrix characterization in breast cancer.

ABSTRACT:

Background

Tumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The ECM has been recognized as an important determinant of breast cancer progression and prognosis. Recent studies have revealed a strong link between ECM remodeling and immune cell infiltration in a variety of tumor types. However, the landscape and specific regulatory mechanisms between ECM and immune microenvironment in breast cancer have not been fully understood.

Methods

Using genomic data and clinical information of breast cancer patients obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, we conducted an extensive multi-omics analysis to explore the heterogeneity and prognostic significance of the ECM microenvironment. Masson and Sirius re

SUBMITTER: Tian Q 

PROVIDER: S-EPMC9493030 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature