Nutritional senolytics and senomorphics: Implications to immune cells metabolism and aging - from theory to practice.

ABSTRACT: Aging is a natural physiological process, but one that poses major challenges in an increasingly aging society prone to greater health risks such as diabetes, cardiovascular disease, cancer, frailty, increased susceptibility to infection, and reduced response to vaccine regimens. The loss of capacity for cell regeneration and the surrounding tissue microenvironment itself is conditioned by genetic, metabolic, and even environmental factors, such as nutrition. The senescence of the immune system (immunosenescence) represents a challenge, especially when associated with the presence of age-related chronic inflammation (inflammaging) and affecting the metabolic programming of immune cells (immunometabolism). These aspects are linked to poorer health outcomes and therefore present an opportuni

SUBMITTER: Luis C 

PROVIDER: S-EPMC9493043 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature