A comprehensive role evaluation and mechanism exploration of POGLUT2 in pan-cancer.

ABSTRACT:

Objective

To evaluate the role of POGLUT2 in pan-cancer through bioinformatics analysis and experimental verification.

Methods

Expression, gene mutation and amplification, methylation, and copy number alteration (CNA) of POGLUT2 were evaluated using The Cancer Genome Atlas (TCGA), Cancer Cell Line Encyclopedia (CCLE), and Genotype-Tissue Expression (GTEx) databases. Moreover, POGLUT2 on survival and disease progression in pan-cancer was performed using TCGA data. Immune infiltration and tumor microenvironment evaluations were assessed by ImmuneScore, ImmuCellAI, and TIMER databases. POGLUT2 correlated drug resistance analysis was performed using the GDSC2 database. Furthermore, POGLUT2 knockdown of breast cancer cells was established, followed by in vitro biological f

SUBMITTER: Xu X 

PROVIDER: S-EPMC9493278 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature