A ferroptosis associated gene signature for predicting prognosis and immune responses in patients with colorectal carcinoma.

ABSTRACT: Background: Colorectal carcinoma (CRC) is one of the most prevalent malignancies globally. Ferroptosis, a novel type of cell death, is critical in the development and treatment of tumors. Objective: This study was designed to establish a genetic signature for ferroptosis which has a predictive effect on the outcomes and immunotherapeutic response of CRC. Methods: Data of CRC patients were retrieved from TCGA and GEO databases. The genes associated with ferroptosis were obtained from GeneCards. The genetic signature for ferroptosis was identified by performing Cox regression analysis. Kaplan-Meier and ROC analysis were performed to assess the prognosis role of the genetic signature. CIBERSORT tool was used to identify a potential association of the genetic signature wit

SUBMITTER: Yan L 

PROVIDER: S-EPMC9493326 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature