Independent validation of a dysphagia dose response model for the selection of head and neck cancer patients to proton therapy.

ABSTRACT:

Background and purpose

The model based approach involves the use of normal tissue complication models for selection of head and neck cancer patients to proton therapy. Our goal was to validate the clinical utility of the related dysphagia model using an independent patient cohort.

Materials and methods

A dataset of 277 head and neck cancer (pharynx and larynx) patients treated with (chemo)radiotherapy between 2019 and 2021 was acquired. For the evaluation of the model discrimination we used statistical metrics such as the sensitivity, specificity and the area under the receiver operating characteristic curve. After the validation we evaluated if the dysphagia model can be improved using the closed testing procedure, the Brier and the Hosmer-Lemeshow score.

Results

The

SUBMITTER: Kalendralis P 

PROVIDER: S-EPMC9493379 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature